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Proceedings Paper

Imaging of atherosclerotic plaques by optical coherence tomography (OCT)
Author(s): Jop Perree; Ton G. J. M. van Leeuwen; Gerard Pasterkamp; Joseph A. Izatt
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Paper Abstract

Optical Coherence Tomography (OCT) is an imaging technique that measures the intensity of light back scattered from sub- surface tissue structures with a very high resolution. This report describes the qualitative and quantitative correlation of OCT and histology measurements for plaque presence and thickness of caps overlying atherosclerotic plaques, respectively. Imaging of samples (n equals 12) was performed from the luminal side with 1300 nm 1 mW or 10 mW light sources, with coherence lengths of 21 and 16 micrometer, respectively. Samples were histologically processed and stained with H&E, EvG and picro-sirius red (PSR) and histological and OCT images were matched. For each sample, the presence of plaque was assessed and the minimal cap thickness was measured by means of histomorphometry and OCT. We found a sensitivity of 6/6 and a specificity of 5/6 for detection of plaques with OCT. Quantitative analysis showed a strong and significant correlation between OCT and histology cap thickness measurements (R2 equals 0.968). Thus, OCT is a sensitive method for detection of plaques, is quantitatively comparable to histology and holds promise as a high-resolution diagnostic tool for visualization of plaque cap thickness.

Paper Details

Date Published: 17 May 2000
PDF: 6 pages
Proc. SPIE 3907, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems X, (17 May 2000); doi: 10.1117/12.386295
Show Author Affiliations
Jop Perree, Univ. of Amsterdam and Interuniversity Cardiology Institute of the Netherlands (Netherlands)
Ton G. J. M. van Leeuwen, Univ. of Amsterdam (Netherlands)
Gerard Pasterkamp, Utrecht Univ. Hospital and Interuniversity Cardiology Institute of the Netherlands (Netherlands)
Joseph A. Izatt, Case Western Reserve Univ. (United States)


Published in SPIE Proceedings Vol. 3907:
Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems X
R. Rox Anderson M.D.; Kenton W. Gregory M.D.; Eugene A. Trowers M.D.; David S. Robinson M.D.; Kenneth Eugene Bartels D.V.M.; Lou Reinisch; Reza S. Malek M.D.; C. Gaelyn Garrett M.D.; Lloyd P. Tate V.D.M.; Hans-Dieter Reidenbach; Timothy A. Woodward M.D.; Kenneth Eugene Bartels D.V.M.; Lawrence S. Bass M.D.; George M. Peavy D.V.M.; C. Gaelyn Garrett M.D.; Kenton W. Gregory M.D.; Nikiforos Kollias; Harvey Lui M.D.; Reza S. Malek M.D.; George M. Peavy D.V.M.; Hans-Dieter Reidenbach; Lou Reinisch; David S. Robinson M.D.; Lloyd P. Tate V.D.M.; Eugene A. Trowers M.D.; Timothy A. Woodward M.D., Editor(s)

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