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Proceedings Paper

Optical coherence tomography in differential diagnosis of skin pathology
Author(s): Natalia D. Gladkova; Galina P. Petrova; Elena Derpaluk; Nikolai K. Nikulin; Ludmila Snopova; Yuri Chumakov; Felix I. Feldchtein; Valentin M. Gelikonov; Grigory V. Gelikonov; Roman V. Kuranov
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Paper Abstract

The capabilities of optical coherence tomography (OCT) for imaging in vivo of optical patterns of pathomorphological processes in the skin and use of their optical patterns in clinical practice for differential diagnosis of dermatoses are presented. Images of skin tissue 0.8 - 1.5 mm deep were acquired with a resolution of 5, 12 and 20 micrometer using three compact fiber OCT devices developed at the Institute of Applied Physics RAS. The acquisition time of images of skin regions 2 - 6 mm in length was 2 - 4 s. The OCT capabilities were analyzed based on the study of 50 patients with different dermatoses. OCT images were interpreted by comparing with parallel histology. It is shown that OCT can detect in vivo optical patterns of morphological alterations in such general papulous dermatoses as lichen ruber planus and psoriasis, a capability that can be used in differential diagnosis of these diseases. Most informative are OCT images obtained with a resolution of 5 micrometer. The results of our study demonstrate the practical importance of OCT imaging for diagnosis of different dermatoses. OCT is noninvasive and, therefore, makes it possible to perform frequent multifocal examination of skin without any adverse effects.

Paper Details

Date Published: 17 May 2000
PDF: 10 pages
Proc. SPIE 3907, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems X, (17 May 2000); doi: 10.1117/12.386243
Show Author Affiliations
Natalia D. Gladkova, Nizhny Novgorod Medical Academy (Russia)
Galina P. Petrova, Nizhny Novgorod Medical Academy (Russia)
Elena Derpaluk, Nizhny Novgorod Dermatovenerologic Research Institute (Russia)
Nikolai K. Nikulin, Nizhny Novgorod Dermatovenerologic Research Institute (Russia)
Ludmila Snopova, Nizhny Novgorod Medical Academy (Russia)
Yuri Chumakov, Nizhny Novgorod Medical Academy (Russia)
Felix I. Feldchtein, Institute of Applied Physics (United States)
Valentin M. Gelikonov, Institute of Applied Physics (Russia)
Grigory V. Gelikonov, Institute of Applied Physics (Russia)
Roman V. Kuranov, Institute of Applied Physics (Russia)

Published in SPIE Proceedings Vol. 3907:
Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems X
R. Rox Anderson; Kenton W. Gregory; Eugene A. Trowers; David S. Robinson; Kenneth Eugene Bartels; Lou Reinisch; Reza S. Malek; C. Gaelyn Garrett; Lloyd P. Tate; Hans-Dieter Reidenbach; Timothy A. Woodward; Kenneth Eugene Bartels; Lawrence S. Bass; George M. Peavy; C. Gaelyn Garrett; Kenton W. Gregory; Nikiforos Kollias; Harvey Lui; Reza S. Malek; George M. Peavy; Hans-Dieter Reidenbach; Lou Reinisch; David S. Robinson; Lloyd P. Tate; Eugene A. Trowers; Timothy A. Woodward, Editor(s)

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