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Proceedings Paper

Noninvasive in-vivo near-infrared vibrational spectroscopic study of lipid and aqueous phases of skin and near-surface tissues
Author(s): Joseph Chaiken; William F. Finney; Karen P. Peterson; Charles M. Peterson; Paul E. Knudson; Ruth S. Weinstock; Paul Lein
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Paper Abstract

We report the use of near infrared vibrational spectroscopy to noninvasively probe the in-vivo lipid and aqueous phases of skin and near surface tissues under conditions of thermal and chemical modulation. We demonstrate thermally induced order- disorder transitions in lipids that can be directly compared to well known behavior of in-vitro samples of phospholipid bilayers and bulk fatty acids. We show reversible chemical modification of aqueous phase proteins which are also directly comparable to well known phenomena involving in-vitro proteins. The results of these studies demonstrate the capacity for noninvasively probing live human tissues on the molecular level using near infrared vibrational spectroscopy. This capacity suggests numerous potential applications ranging from assessing the efficacy of cosmetics, skin care treatments and transdermal therapeutic agents/treatments to serving as a diagnostic of various skin ailments, e.g. melanoma.

Paper Details

Date Published: 17 May 2000
PDF: 9 pages
Proc. SPIE 3907, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems X, (17 May 2000); doi: 10.1117/12.386241
Show Author Affiliations
Joseph Chaiken, Syracuse Univ., Laser Chemical Corp., and LighTouch Medical Inc. (United States)
William F. Finney, Syracuse Univ., Laser Chemical Corp., and LighTouch Medical Inc. (United States)
Karen P. Peterson, LighTouch Medical Inc. (United States)
Charles M. Peterson, LighTouch Medical Inc. (United States)
Paul E. Knudson, SUNY Health Science Ctr. at Syracuse (United States)
Ruth S. Weinstock, SUNY Health Science Ctr. at Syracuse (United States)
Paul Lein, LighTouch Medical Inc. (United States)


Published in SPIE Proceedings Vol. 3907:
Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems X
R. Rox Anderson; Kenton W. Gregory; Eugene A. Trowers; David S. Robinson; Kenneth Eugene Bartels; Lou Reinisch; Reza S. Malek; C. Gaelyn Garrett; Lloyd P. Tate; Hans-Dieter Reidenbach; Timothy A. Woodward; Kenneth Eugene Bartels; Lawrence S. Bass; George M. Peavy; C. Gaelyn Garrett; Kenton W. Gregory; Nikiforos Kollias; Harvey Lui; Reza S. Malek; George M. Peavy; Hans-Dieter Reidenbach; Lou Reinisch; David S. Robinson; Lloyd P. Tate; Eugene A. Trowers; Timothy A. Woodward, Editor(s)

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