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Proceedings Paper

Endovascular photodynamic therapy inhibits intimal hyperplasia after PTA in a rat model
Author(s): Edward E. Gabeler; Richard van Hillegersberg; R. G. Statius van Eps; Wim Sluiter; Hero van Urk
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Paper Abstract

Background: Vascular restenosis due to intimal hyperplasia (IH) and negative vascular remodeling (shrinkage) attenuates long-term patency of interventions like bypass procedures, endarterectomies and PT(C)As. Endovascular photodynamic therapy (PDT) may be an adjuvant approach based on intracellular photoactivation of 5-aminolevulinic acid (ALA) induced protoporphyrin IX (PP IX) resulting in local cytotoxicity. Aim: To prevent restenosis by inhibiting IH with endovascular PDT. Methods: Male Wistar rats (n equals 33) were subdivided into two groups; one experimental group; the PTA + PDT group (N equals 18), in which illumination with either 0, 12.5, 25 and 50 J/cm diffuser length was applied at 100 mW/cm diffuser length; one control group; the PTA group in which IH was induced after balloon denudation of the right iliacal artery (n equals 15). Results: Morfometric analysis showed that IH developed from 0.02 plus or minus 0.02 mm2 at 1 week to 0.13 plus or minus 0.04 mm2 at 4 weeks in the PTA group. In the PTA + PDT-group with 50 J/cm diffuser length still no IH (0.002 plus or minus 0.003 mm2) developed after 4 weeks. Conclusion: Endovascular PDT prevents formation of IH measured 4 weeks post PTA. An optimal light dosimetry of 50 J/cm diffuser length at 3 hours after ALA application was found in this IH model. Therefore, endovascular PDT is a promising therapy to prevent restenosis after vascular interventions.

Paper Details

Date Published: 17 May 2000
PDF: 7 pages
Proc. SPIE 3907, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems X, (17 May 2000); doi: 10.1117/12.386238
Show Author Affiliations
Edward E. Gabeler, Erasmus Medical Ctr. of Rotterdam (Netherlands)
Richard van Hillegersberg, Erasmus Medical Ctr. of Rotterdam (Netherlands)
R. G. Statius van Eps, Erasmus Medical Ctr. of Rotterdam (Netherlands)
Wim Sluiter, Erasmus Medical Ctr. of Rotterdam (Netherlands)
Hero van Urk, Erasmus Medical Ctr. of Rotterdam (Netherlands)

Published in SPIE Proceedings Vol. 3907:
Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems X
R. Rox Anderson; Kenton W. Gregory; Eugene A. Trowers; David S. Robinson; Kenneth Eugene Bartels; Lou Reinisch; Reza S. Malek; C. Gaelyn Garrett; Lloyd P. Tate; Hans-Dieter Reidenbach; Timothy A. Woodward; Kenneth Eugene Bartels; Lawrence S. Bass; George M. Peavy; C. Gaelyn Garrett; Kenton W. Gregory; Nikiforos Kollias; Harvey Lui; Reza S. Malek; George M. Peavy; Hans-Dieter Reidenbach; Lou Reinisch; David S. Robinson; Lloyd P. Tate; Eugene A. Trowers; Timothy A. Woodward, Editor(s)

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