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Proceedings Paper

Noninvasive in-vivo tissue-modulated near-infrared vibrational spectroscopic study of mobile and static tissues: blood chemistry
Author(s): Joseph Chaiken; William F. Finney; Charles M. Peterson; Karen P. Peterson; Paul E. Knudson; Ruth S. Weinstock; Paul Lein
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Paper Abstract

We report the first noninvasive Raman spectra of in vivo human blood. 'Tissue modulation' involves the use of thermal and/or mechanical stimulus to produce particular spatiotemporal distributions of mobile tissues, i.e. capillary blood, among nonmobile tissues, i.e. epidermis. Using this approach we have obtained three mutually independent lines of evidence, which unequivocally associate Raman spectra we have obtained with human blood. These spectral compare well with published spectra from other researchers of in vitro human blood. The results of a recent clinical study comparing our noninvasive in vivo spectroscopic measurements with simultaneous conventional in vitro measurements clearly demonstrate the efficacy of the tissue modulation approach. These results will be discussed in the context of noninvasive monitoring of a variety of analytes, i.e. glucose.

Paper Details

Date Published: 8 May 2000
PDF: 9 pages
Proc. SPIE 3918, Biomedical Spectroscopy: Vibrational Spectroscopy and Other Novel Techniques, (8 May 2000); doi: 10.1117/12.384957
Show Author Affiliations
Joseph Chaiken, Syracuse Univ., Laser Chemical Corp., and LighTouch Medical (United States)
William F. Finney, Syracuse Univ. (United States)
Charles M. Peterson, LighTouch Medical (United States)
Karen P. Peterson, LighTouch Medical (United States)
Paul E. Knudson, SUNY Health Science Ctr. (United States)
Ruth S. Weinstock, SUNY Health Science Ctr. (United States)
Paul Lein, LighTouch Medical (United States)

Published in SPIE Proceedings Vol. 3918:
Biomedical Spectroscopy: Vibrational Spectroscopy and Other Novel Techniques
Anita Mahadevan-Jansen; Gerwin J. Puppels, Editor(s)

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