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Proceedings Paper

Characterization of normal and native oral cancerous tissues by infrared spectroscopy
Author(s): Nammalver Vengadesan; D. Koteeswaran; Prakasa Rao Aruna; K. Muthuvelu; Singaravelu Ganesan
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Paper Abstract

Fourier transform IR spectroscopy of normal and cancerous human oral tissues have been studied in the mid IR frequency region. From this study, we observed that the cancerous tissues are having higher absorption than that of normal one. Further it is observed that there is a 13 cm-1 red shift for cancerous samples with respect to normal tissues at their maximum absorption. In order to quantify the spectral differences between normal and cancerous tissues, two ratio parameters R1 equals I1650/I1546 and R2 equals I1650/I1384 are introduced. From the ratio parameter R1, it is found that the critical value 2.1 classify the malignant from normal with a 93 percent sensitivity and 80 percent specificity. Similarity a critical value 3 is given for the ratio parameter R2 yielding 80 percent sensitivity and 100 percent specificity.

Paper Details

Date Published: 8 May 2000
PDF: 5 pages
Proc. SPIE 3918, Biomedical Spectroscopy: Vibrational Spectroscopy and Other Novel Techniques, (8 May 2000); doi: 10.1117/12.384954
Show Author Affiliations
Nammalver Vengadesan, Anna Univ. (India)
D. Koteeswaran, Government Aringnar Anna Memorial Cancer Hospital (India)
Prakasa Rao Aruna, Anna Univ. (India)
K. Muthuvelu, Government Aringnar Anna Memorial Cancer Hospital (India)
Singaravelu Ganesan, Anna Univ. (India)

Published in SPIE Proceedings Vol. 3918:
Biomedical Spectroscopy: Vibrational Spectroscopy and Other Novel Techniques
Anita Mahadevan-Jansen; Gerwin J. Puppels, Editor(s)

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