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Proceedings Paper

Progress in the detection of neoplastic progress and cancer by Raman spectroscopy
Author(s): Tom C. Bakker Schut; Nicholas Stone; Catherine A. Kendall; Hugh Barr; Hajo A. Bruining; Gerwin J. Puppels
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Paper Abstract

Early detection of cancer is important because of the improved survival rates when the cancer is treated early. We study the application of NIR Raman spectroscopy for detection of dysplasia because this technique is sensitive to the small changes in molecular invasive in vivo detection using fiber-optic probes. The result of an in vitro study to detect neoplastic progress of esophageal Barrett's esophageal tissue will be presented. Using multivariate statistics, we developed three different linear discriminant analysis classification models to predict tissue type on the basis of the measured spectrum. Spectra of normal, metaplastic and dysplasia tissue could be discriminated with an accuracy of up to 88 percent. Therefore Raman spectroscopy seems to be a very suitable technique to detect dysplasia in Barrett's esophageal tissue.

Paper Details

Date Published: 8 May 2000
PDF: 8 pages
Proc. SPIE 3918, Biomedical Spectroscopy: Vibrational Spectroscopy and Other Novel Techniques, (8 May 2000); doi: 10.1117/12.384932
Show Author Affiliations
Tom C. Bakker Schut, Erasmus Medical Ctr. Rotterdam (Netherlands)
Nicholas Stone, Gloucestershire Royal Hospital (United Kingdom)
Catherine A. Kendall, Gloucestershire Royal Hospital (United Kingdom)
Hugh Barr, Gloucestershire Royal Hospital (United Kingdom)
Hajo A. Bruining, Erasmus Medical Ctr. Rotterdam (Netherlands)
Gerwin J. Puppels, Erasmus Medical Ctr. Rotterdam (Netherlands)

Published in SPIE Proceedings Vol. 3918:
Biomedical Spectroscopy: Vibrational Spectroscopy and Other Novel Techniques
Anita Mahadevan-Jansen; Gerwin J. Puppels, Editor(s)

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