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Proceedings Paper

Optical measurement of photosensitizer concentration using a probe with a small source-detector fiber separation
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Paper Abstract

We present a novel minimally invasive method to measure the concentration of photodynamic therapy drugs in real time. The method is based on measurements of backscattered and fluorescence light using a steady state fluorescence spectrometer. The ratio of the fluorescence to scattered light is found to be linearly proportional to the absorption coefficient of the photosensitizer. The fiber-optic probe used for the measurements has a small source-detector separation, therefore the measurements could be performed through the working channel of an endoscope.

Paper Details

Date Published: 3 May 2000
PDF: 9 pages
Proc. SPIE 3911, Biomedical Diagnostic, Guidance, and Surgical-Assist Systems II, (3 May 2000); doi: 10.1117/12.384915
Show Author Affiliations
Murat Canpolat, Los Alamos National Lab. (United States)
Judith R. Mourant, Los Alamos National Lab. (United States)

Published in SPIE Proceedings Vol. 3911:
Biomedical Diagnostic, Guidance, and Surgical-Assist Systems II
Tuan Vo-Dinh; Warren S. Grundfest; David A. Benaron, Editor(s)

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