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Proceedings Paper

Quantitative muscle oxygenation measurement using NIRS with correction for the influence of a fat layer: comparison of oxygen consumption rates with measurements by other techniques
Author(s): Masatsugu Niwayama; Takatumi Hamaoka; Ling Lin; Jun Shao; Nobuki Kudo; Chietsugu Katoh; Katsuyuki Yamamoto
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Paper Abstract

The inhomogeneity of tissue structure greatly affects the sensitivity of tissue oxygenation measurement by near-IR spectroscopy (NIRS). We have proposed a method for correcting the influence of a subcutaneous fat layer on muscle oxygenation measurements. In this study, we validated our correction method by measuring oxygen consumption rates of the forearm muscle and comparing the measurements with those obtained by other techniques. 31P-magnetic resonance spectroscopy and positron emission tomography (PET). In NIRS, Vo2mus was obtained from the falling rate of oxygenation in ischaemia tests. The values of Vo2mos were corrected using a curve of measurement sensitivity against fat layer thicknesses, which were measured by ultrasonography. The corrected Vo2mus showed greater values and less variation between individuals than did the uncorrected one. In the 31P-NMR measurements on 10 subjects, Vo2mus was estimated from changes in phosphocreatine. The corrected Vo2mus in NIRS correlated well with the measurements by 31P-NMR compared to the uncorrected Vo2mus. This result suggested that our correction method is valid. Vo2mus was also measured using PET in one of the authors. The measured values by NIRS. 31P-NMR and PET were 0.22, 0.17, 0.24 ml 100g-1 min-1, respectively. The measurement by NIRS using our correction method was in an acceptable range.

Paper Details

Date Published: 3 May 2000
PDF: 10 pages
Proc. SPIE 3911, Biomedical Diagnostic, Guidance, and Surgical-Assist Systems II, (3 May 2000); doi: 10.1117/12.384911
Show Author Affiliations
Masatsugu Niwayama, Hokkaido Univ. (Japan)
Takatumi Hamaoka, Tokyo Medical College (Japan)
Ling Lin, Hokkaido Univ. (Japan)
Jun Shao, Hokkaido Univ. (United States)
Nobuki Kudo, Hokkaido Univ. (Japan)
Chietsugu Katoh, Hokkaido Univ. Graduate School of Medicine (Japan)
Katsuyuki Yamamoto, Hokkaido Univ. (Japan)

Published in SPIE Proceedings Vol. 3911:
Biomedical Diagnostic, Guidance, and Surgical-Assist Systems II
Tuan Vo-Dinh; Warren S. Grundfest M.D.; David A. Benaron M.D., Editor(s)

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