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Proceedings Paper

Optical fiber extrinsic Fabry-Perot interferometric (EFPI)-based biosensors
Author(s): Jennifer L. Elster; Mark E. Jones; Mishell K. Evans; Shannon M. Lenahan; Christopher A. Boyce; William H. Velander; Roger VanTassell
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Paper Abstract

A novel system incorporating optical fiber extrinsic Fabry- Perot interferometric (EFPI)-based sensors for rapid detection of biological targets is presented. With the appropriate configuration, the EFPI senor is able to measure key environmental parameters by monitoring the interferometric fringes resulting from an optical path differences of reflected signals. The optical fiber EFPI sensor has been demonstrated for strain, pressure, and temperature measurements and can be readily modified for refractive index measurements by allowing solutions to flow into an open cavity. The sensor allows for highly sensitive, real-time, refractive index measurements and by applying affinity coatings containing ligands within this cavity, specific binding of target molecules can be accomplished. As target molecules bind to the coating, there is an increased density within the film, causing a measurable refractive index change that correlates to the concentration of detected target molecules. This sensor platform offers enhanced sensing capabilities for clinical diagnostics, pharmaceutical screening, environmental monitoring, food pathogen detection, biological warfare agent detection, and industrial bioprocessing. Promising applications also exist for process monitoring within the food/beverage, petroleum, and chemical industry.

Paper Details

Date Published: 3 May 2000
PDF: 8 pages
Proc. SPIE 3911, Biomedical Diagnostic, Guidance, and Surgical-Assist Systems II, (3 May 2000); doi: 10.1117/12.384892
Show Author Affiliations
Jennifer L. Elster, Luna Innovations (United States)
Mark E. Jones, Luna Innovations (United States)
Mishell K. Evans, Luna Innovations (United States)
Shannon M. Lenahan, Luna Innovations (United States)
Christopher A. Boyce, Luna Innovations (United States)
William H. Velander, Virginia Polytechnic Institute and State Univ. (United States)
Roger VanTassell, Virginia Polytechnic Institute and State Univ. (United States)

Published in SPIE Proceedings Vol. 3911:
Biomedical Diagnostic, Guidance, and Surgical-Assist Systems II
Tuan Vo-Dinh; Warren S. Grundfest M.D.; David A. Benaron M.D., Editor(s)

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