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Proceedings Paper

Free-electron laser tissue-soldering in vitro with an albumin solder
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Paper Abstract

The purpose of this study was to explore the feasibility of using a free-electron laser (FEL) to photothermally coagulate an albumin solder for laser-assisted incision closure. A 50%(w/v) bovine serum albumin solder was used to repair an incision in bovine aorta. The solder was coagulated by targeting absorption peaks in the solder infrared absorption spectrum using the FEL. Acute breaking strengths of repaired incisions were measured and the data analyzed by one-way ANOVA (P < 0.05). Multiple comparisons of means were performed using the Newman-Keuls test. The solder absorption spectrum from 2 - 10 microns was similar to water with an additional peak at 6.45 microns (amide II) due to the albumin. Preliminary results indicated that wavelengths at or very close to the absorption peaks were excessively absorbed, resulting in only the top surface of the solder being coagulated. Using wavelengths at points of weak absorption on the water absorption curve yielded better results.

Paper Details

Date Published: 28 April 2000
PDF: 9 pages
Proc. SPIE 3925, Biomedical Applications of Free-Electron Lasers, (28 April 2000); doi: 10.1117/12.384257
Show Author Affiliations
Brian S. Sorg, Univ. of Texas/Austin (United States)
Bernard Choi, Univ. of Texas/Austin (United States)
Karen M. McNally-Heintzelman, Univ. of Texas/Austin (United States)
E. Duco Jansen, Vanderbilt Univ. (United States)
Ashley J. Welch, Univ. of Texas/Austin (United States)

Published in SPIE Proceedings Vol. 3925:
Biomedical Applications of Free-Electron Lasers
Glenn S. Edwards; John Clark Sutherland, Editor(s)

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