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Proceedings Paper

Proton pumps, angiogenesis, and metastatic breast cancer
Author(s): Jose D. Rojas; Shankar C. Sanka; Defeng Luo; Christian Busch; Gloria M. Martinez; Mary J. C. Hendrix; Raul Martinez-Zaguilan
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Paper Abstract

We have previously shown the relationship between metastatic potential and plasmalemmal V-H+-ATPase (pmV-ATPase) expression in tumor cells. This led us to hypothesize that pmV-ATPase activity is involved in invasion. Angiogenesis involves invasion of adjacent tissues by microvascular endothelial cells, thus we hypothesized that pmV-ATPases contribute to pHin regulation and invasion in microvascular endothelial cells.

Paper Details

Date Published: 26 April 2000
PDF: 12 pages
Proc. SPIE 3924, Molecular Imaging: Reporters, Dyes, Markers, and Instrumentation, (26 April 2000); doi: 10.1117/12.384241
Show Author Affiliations
Jose D. Rojas, Texas Tech Univ. Health Sciences Ctr. (United States)
Shankar C. Sanka, Texas Tech Univ. Health Sciences Ctr. (United States)
Defeng Luo, Texas Tech Univ. Health Sciences Ctr. (United States)
Christian Busch, Texas Tech Univ. Health Sciences Ctr. (United States)
Gloria M. Martinez, Texas Tech Univ. Health Sciences Ctr. (United States)
Mary J. C. Hendrix, Univ. of Iowa College of Medicine (United States)
Raul Martinez-Zaguilan, Texas Tech Univ. Health Sciences Ctr. (United States)


Published in SPIE Proceedings Vol. 3924:
Molecular Imaging: Reporters, Dyes, Markers, and Instrumentation
Darryl J. Bornhop; Kai Licha, Editor(s)

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