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Proceedings Paper

Ca2+ homeostasis in microvascular endothelial cells from an insulin-dependent diabetic model: role of endosomes/lysosomes
Author(s): Shankar C. Sanka; David C. Bennett; Jose D. Rojas; Geraldine B. Tasby; Cynthia J. Meininger; Guoyao Wu; Donald E. Wesson; Curtis Michael Pfarr; Raul Martinez-Zaguilan
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Paper Abstract

Cytosolic Ca2+ ([Ca2+]cyt) regulates several cellular functions, e.g. cell growth, contraction, secretion, etc. In many cell types, ion homeostasis appears to be coupled with glucose metabolism. In certain cell types, a strict coupling between glycolysis and the activity of Sarcoplasmic/Endoplasmic Reticulum Ca2+-ATPases (SERCA) has been suggested. Glucose metabolism is altered in diabetes. We hypothesize that: (1) Ca2+ homeostasis is altered in microvascular endothelial cells from diabetic animals due to the dysfunction of glycolysis coupling the activity of SERCA; (2) endosomal/lysosomal compartments expressing SERCA are involved in the dysfunction associated with diabetes.

Paper Details

Date Published: 26 April 2000
PDF: 11 pages
Proc. SPIE 3924, Molecular Imaging: Reporters, Dyes, Markers, and Instrumentation, (26 April 2000); doi: 10.1117/12.384240
Show Author Affiliations
Shankar C. Sanka, Texas Tech Univ. Health Sciences Ctr. (United States)
David C. Bennett, Texas Tech Univ. Health Sciences Ctr. (United States)
Jose D. Rojas, Texas Tech Univ. Health Sciences Ctr. (United States)
Geraldine B. Tasby, Texas Tech Univ. Health Sciences Ctr. (United States)
Cynthia J. Meininger, Texas A&M Univ. (United States)
Guoyao Wu, Texas Tech Univ. Health Sciences Ctr. (United States)
Donald E. Wesson, Texas Tech Univ. Health Sciences Ctr. (United States)
Curtis Michael Pfarr, Texas Tech Univ. Health Sciences Ctr. (United States)
Raul Martinez-Zaguilan, Texas Tech Univ. Health Sciences Ctr. (United States)


Published in SPIE Proceedings Vol. 3924:
Molecular Imaging: Reporters, Dyes, Markers, and Instrumentation
Darryl J. Bornhop; Kai Licha, Editor(s)

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