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Proceedings Paper

Development of an advanced digital detection system for multidrug resistant tuberculosis screening
Author(s): Michelle D. Simkulet; Jeffrey Andrew Beckstead; Brian C. Gilman; Savco Bardarov; James Castracane; William R. Jacobs
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Paper Abstract

Tuberculosis (TB) remains the leading cause of death in the world from a single infectious disease and the threat is becoming more critical with the emergence and spread of multi-drug resistant tuberculosis (MDR-TB). Existing methods for detection of various strains of mycobacterium tuberculosis are complex, time consuming and expensive, and therefore, not suitable for use in developing countries where the spread of the disease is most rampant. Currently, a digital detection system based on advanced digital imaging technology, including CMOS and image intensification technology, is being developed by InterScience, Inc. for use with the luciferase reporter mycobacteriophages technique as developed at the Albert Einstein College of Medicine. This compact, low cost and high sensitivity system for rapid diagnosis and drug susceptibility testing for TB will have an immediate impact for both research and clinical applications. It is envisioned that the instrument will be suitable for use as a portable tool for rapid screening of MDR-TB in both developed and developing countries. The development of the system, recent results and a comparison to competing technologies will be presented.

Paper Details

Date Published: 26 April 2000
PDF: 7 pages
Proc. SPIE 3924, Molecular Imaging: Reporters, Dyes, Markers, and Instrumentation, (26 April 2000); doi: 10.1117/12.384239
Show Author Affiliations
Michelle D. Simkulet, InterScience, Inc. (United States)
Jeffrey Andrew Beckstead, InterScience, Inc. (United States)
Brian C. Gilman, InterScience, Inc. (United States)
Savco Bardarov, Yeshiva Univ. College of Medicine (United States)
James Castracane, SUNY/Albany (United States)
William R. Jacobs, Yeshiva Univ. College of Medicine (United States)


Published in SPIE Proceedings Vol. 3924:
Molecular Imaging: Reporters, Dyes, Markers, and Instrumentation
Darryl J. Bornhop; Kai Licha, Editor(s)

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