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Proceedings Paper

Creation of a virtual cutaneous tissue bank
Author(s): William A. LaFramboise; Sujal Shah; R. W. Hoy; D. Letbetter; P. Petrosko; R. Vennare; Peter C. Johnson
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Paper Abstract

Cellular and non-cellular constituents of skin contain fundamental morphometric features and structural patterns that correlate with tissue function. High resolution digital image acquisitions performed using an automated system and proprietary software to assemble adjacent images and create a contiguous, lossless, digital representation of individual microscope slide specimens. Serial extraction, evaluation and statistical analysis of cutaneous feature is performed utilizing an automated analysis system, to derive normal cutaneous parameters comprising essential structural skin components. Automated digital cutaneous analysis allows for fast extraction of microanatomic dat with accuracy approximating manual measurement. The process provides rapid assessment of feature both within individual specimens and across sample populations. The images, component data, and statistical analysis comprise a bioinformatics database to serve as an architectural blueprint for skin tissue engineering and as a diagnostic standard of comparison for pathologic specimens.

Paper Details

Date Published: 27 April 2000
PDF: 4 pages
Proc. SPIE 3921, Optical Diagnostics of Living Cells III, (27 April 2000); doi: 10.1117/12.384233
Show Author Affiliations
William A. LaFramboise, TissueInformatics, Inc. (United States)
Sujal Shah, TissueInformatics, Inc. (United States)
R. W. Hoy, TissueInformatics, Inc. (United States)
D. Letbetter, TissueInformatics, Inc. (United States)
P. Petrosko, TissueInformatics, Inc. (United States)
R. Vennare, TissueInformatics, Inc. (United States)
Peter C. Johnson, TissueInformatics, Inc. (United States)


Published in SPIE Proceedings Vol. 3921:
Optical Diagnostics of Living Cells III
Daniel L. Farkas; Daniel L. Farkas; Robert C. Leif, Editor(s)

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