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Proceedings Paper

High-resolution x-ray CT screening of mutant mouse models
Author(s): Michael J. Paulus; Shaun S. Gleason; Hamed Sari-Sarraf; Dabney K. Johnson; Charmaine J. Foltz; Derek W. Austin; M. Evangeline Easterly; Edward J. Michaud; Madhu S. Dhar; Patricia R. Hunsicker; J. W. Wall; M. Schell
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Paper Abstract

A dedicated small animal x-ray computed tomography system has been developed to screen mutagenized mice for anatomical phenotypes. The key components of the data acquisition instrumentation are described along with the system performance parameters. Image reconstruction, visualization and segmentation software algorithms are described. Two contrast media regimens are described and representative studies of mice with adipose, soft and skeletal tissue abnormalities are presented.

Paper Details

Date Published: 27 April 2000
PDF: 10 pages
Proc. SPIE 3921, Optical Diagnostics of Living Cells III, (27 April 2000); doi: 10.1117/12.384221
Show Author Affiliations
Michael J. Paulus, Oak Ridge National Lab. (United States)
Shaun S. Gleason, Oak Ridge National Lab. (United States)
Hamed Sari-Sarraf, Oak Ridge National Lab. (United States)
Dabney K. Johnson, Oak Ridge National Lab. (United States)
Charmaine J. Foltz, Oak Ridge National Lab. (United States)
Derek W. Austin, Oak Ridge National Lab. (United States)
M. Evangeline Easterly, Oak Ridge National Lab. (United States)
Edward J. Michaud, Oak Ridge National Lab. (United States)
Madhu S. Dhar, Oak Ridge National Lab. (United States)
Patricia R. Hunsicker, Oak Ridge National Lab. (United States)
J. W. Wall, Univ. of Tennessee/Knoxville Medical Ctr. (United States)
M. Schell, Univ. of Tennessee/Knoxville Medical Ctr. (United States)


Published in SPIE Proceedings Vol. 3921:
Optical Diagnostics of Living Cells III
Daniel L. Farkas; Robert C. Leif; Daniel L. Farkas, Editor(s)

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