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Proceedings Paper

Reconstruction of 3D radial distribution of interphase chromatin in lymphocyte nucleus for various diseases
Author(s): Igor Patrickeyev; Peter Frick; Alexander V. Zhukotsky
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Paper Abstract

The wavelet tomography is used for statistical reconstruction of a lymphocyte nucleus for various diseases. The restored parameter is a probability density function (PDF) of radial distribution of condensed chromatin. In this content, PDF describes the cross-section of the nuclear structure of chromatin. Initial dat for reconstruction is the histogram of the chromatin granules, i.e. the number of granules versus the distance for the center of projection. This work is concerned with lymphocyte nuclei of peripheral blood for four groups of patients: control group; those who live in the area affected by the Chernobyl accident; mieloid group; leucose group. In contrast to the previous work, the new criteria of regularization is developed and used.

Paper Details

Date Published: 27 April 2000
PDF: 11 pages
Proc. SPIE 3921, Optical Diagnostics of Living Cells III, (27 April 2000); doi: 10.1117/12.384205
Show Author Affiliations
Igor Patrickeyev, Institute of Continuous Media Mechanics (Russia)
Peter Frick, Institute of Continuous Media Mechanics (Russia)
Alexander V. Zhukotsky, Institute of Physical and Chemical Medicine (Russia)

Published in SPIE Proceedings Vol. 3921:
Optical Diagnostics of Living Cells III
Daniel L. Farkas; Daniel L. Farkas; Robert C. Leif, Editor(s)

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