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Proceedings Paper

Tomographic microscope with superimposition of fluorescence and interference contrast
Author(s): Lidia I. Poplevina; Theodor V. Bulygin; Gennady G. Levin; Gennady N. Vishnyakov; Elena V. Pecherskih
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Paper Abstract

Fluorescence microscopy is a powerful instrument for the study of cells and other biological objects. One of the actual tasks of the modern microscopy is the study of drugs transportation in cells and it's affect on the different cell organelles. The authors have proposed and tested the new type of the microscope with superimposed interference and fluorescence images of the living cell. The optical setup of the fluorescence interference microscope is based on confocal Linnik's type interference microscope. The fluorescence image gives the information about the distribution of drugs in different parts of the cell. The interference image gives the information about the distribution of dry mass or protein in the different parts of the cell.

Paper Details

Date Published: 2 May 2000
PDF: 7 pages
Proc. SPIE 3919, Three-Dimensional and Multidimensional Microscopy: Image Acquisition Processing VII, (2 May 2000); doi: 10.1117/12.384179
Show Author Affiliations
Lidia I. Poplevina, Moscow Univ. of Electronic Technology (Russia)
Theodor V. Bulygin, All-Russian Research Institute for Optophysical Measurements (Russia)
Gennady G. Levin, Moscow State Technical Univ. (Russia)
Gennady N. Vishnyakov, Moscow State Technical Univ. (Russia)
Elena V. Pecherskih, Moscow Hertzen Research Oncological Institute (Russia)


Published in SPIE Proceedings Vol. 3919:
Three-Dimensional and Multidimensional Microscopy: Image Acquisition Processing VII
Jose-Angel Conchello; Carol J. Cogswell; Andrew G. Tescher; Tony Wilson, Editor(s)

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