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Proceedings Paper

Analyses of the sample volume for fiber optics and confocal detecting probe in backscattered spectral investigations of the skin
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Paper Abstract

Photon migration through skin tissue leads to a poorly defined 'sampling volume' so that the optical signal represents a spatial average over cell layers 1 mm deep or more. This problem is well known in the field of Laser Doppler Flowmetry. The current work is to theoretically investigate to what extent we can localize the sampling volume of reflectance spectroscopy to the upper layers of skin. The results of Monte Carlo simulation of the degree of photon spatial localization for different kind of optical probes are given. Such localization is very important for the clinical interpretation of the results, as capillary loops are responsible for the delivery of nutrients to the epidermis, whereas deeper vessels are primarily thermo regulatory in function.

Paper Details

Date Published: 28 April 2000
PDF: 7 pages
Proc. SPIE 3915, Coherence Domain Optical Methods in Biomedical Science and Clinical Applications IV, (28 April 2000); doi: 10.1117/12.384160
Show Author Affiliations
Igor Victorovich Meglinski, Univ. of Exeter and Saratov State Univ. (United Kingdom)
Stephen John Matcher, Univ. of Exeter (United Kingdom)

Published in SPIE Proceedings Vol. 3915:
Coherence Domain Optical Methods in Biomedical Science and Clinical Applications IV
Valery V. Tuchin; Joseph A. Izatt; James G. Fujimoto, Editor(s)

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