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Proceedings Paper

Monte-Carlo simulations of arterial imaging with optical coherence tomography
Author(s): Peter A. Amendt; Kent G. Estabrook; Matthew J. Everett; Richard A. London; Duncan J. Maitland; George B. Zimmerman; Bill W. Colston; Luiz Barroca Da Silva; Ujwal S. Sathyam
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Paper Abstract

The laser-tissue interaction code LATIS is used to analyze photon scattering histories representative of optical coherence tomography (OCT) experiments performed at Lawrence Livermore National Laboratory. Monte Carlo photonics with Henyey-Greenstein anisotropic scattering is implemented and used to simulate signal discrimination of intravascular structure. An analytic model is developed and used to obtain a scaling law for optimization of the OCT signal and to validate Monte Carlo photonics. The appropriateness of the Henyey-Greenstein phase function is studied by direct comparison with more detailed Mie scattering theory using an ensemble of spherical dielectric scatterers. Modest differences are found between the two prescription for describing photon angular scattering in tissue. In particular, the Mie scattering phase functions provide less overall reflectance signal but more signal contrast compared to the Henyey-Greenstein formulation.

Paper Details

Date Published: 28 April 2000
PDF: 12 pages
Proc. SPIE 3915, Coherence Domain Optical Methods in Biomedical Science and Clinical Applications IV, (28 April 2000); doi: 10.1117/12.384157
Show Author Affiliations
Peter A. Amendt, Lawrence Livermore National Lab. (United States)
Kent G. Estabrook, Lawrence Livermore National Lab. (United States)
Matthew J. Everett, Lawrence Livermore National Lab. (United States)
Richard A. London, Lawrence Livermore National Lab. (United States)
Duncan J. Maitland, Lawrence Livermore National Lab. (United States)
George B. Zimmerman, Lawrence Livermore National Lab. (United States)
Bill W. Colston, Lawrence Livermore National Lab. (United States)
Luiz Barroca Da Silva, Lawrence Livermore National Lab. (United States)
Ujwal S. Sathyam, Lawrence Livermore National Lab. (United States)


Published in SPIE Proceedings Vol. 3915:
Coherence Domain Optical Methods in Biomedical Science and Clinical Applications IV
Valery V. Tuchin; Joseph A. Izatt; James G. Fujimoto, Editor(s)

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