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Proceedings Paper

Polarized light propagation through tissue and tissue phantoms
Author(s): Vanitha Sankaran M.D.; Joseph T. Walsh Jr.; Duncan J. Maitland
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Paper Abstract

We show that standard tissue phantoms can be sued to mimic the intensity and polarization properties of tissue. Polarized light propagation through biologic tissue is typically studied using tissue phantoms consisting of dilute aqueous suspensions of microspheres. The dilute phantoms can empirically match tissue polarization and intensity properties. One discrepancy between the dilute phantoms and tissue exist: common tissue phantoms, such as dilute Intralipid and dilute 1-micrometers -diameter polystyrene microsphere suspension, depolarize linearly polarized light more quickly than circular polarized light. In dense tissue, however, where scatterers are often locate din close proximity to one another, circularly polarized light is depolarized similar to more quickly than linearly polarized light. We also demonstrate that polarized light is depolarized similar to or more quickly than linearly polarized light. We also demonstrate that polarized light propagates differently in dilute versus densely packed microsphere suspensions, which may account for the differences seen between polarized light propagation in common dilute tissue phantoms versus dense biologic tissue.

Paper Details

Date Published: 28 April 2000
PDF: 9 pages
Proc. SPIE 3915, Coherence Domain Optical Methods in Biomedical Science and Clinical Applications IV, (28 April 2000); doi: 10.1117/12.384154
Show Author Affiliations
Vanitha Sankaran M.D., Northwestern Univ. and Lawrence Livermore National Lab. (United States)
Joseph T. Walsh Jr., Northwestern Univ. (United States)
Duncan J. Maitland, Lawrence Livermore National Lab. (United States)


Published in SPIE Proceedings Vol. 3915:
Coherence Domain Optical Methods in Biomedical Science and Clinical Applications IV
Valery V. Tuchin; Joseph A. Izatt; James G. Fujimoto, Editor(s)

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