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Proceedings Paper

DNA and protein change in tissues probed by Kubelka-Munk spectral function
Author(s): Yuanlong Yang; Edward J. Celmer M.D.; Jason A. Koutcher M.D.; Robert R. Alfano
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Paper Abstract

Normal, fibroadenoma, malignant, and adipose breast tissues were investigated using Kubelka-Munk Spectral Function (KMSF). The spectral features in KMSF were identified and compared with absorption spectra determined by transmission measurements. A specified spectral feature measured in adipose tissue was assigned to (beta) -carotene, which can be used to separate fat form other molecular components in breast tissues. The peaks of (KMF) at 260nm and 280nm were attributed to DNA and proteins. The signal amplitude over 255nm to 265nm and 275nm to 285nm were found to be different for malignant fibroadenoma, and normal tissues.

Paper Details

Date Published: 19 April 2000
PDF: 4 pages
Proc. SPIE 3917, Optical Biopsy III, (19 April 2000); doi: 10.1117/12.382744
Show Author Affiliations
Yuanlong Yang, CUNY/City College (United States)
Edward J. Celmer M.D., St. Vincent's Medical Ctr. of Richmond (United States)
Jason A. Koutcher M.D., Memorial Sloan-Kettering Cancer Ctr. (United States)
Robert R. Alfano, CUNY/City College (United States)


Published in SPIE Proceedings Vol. 3917:
Optical Biopsy III
Robert R. Alfano, Editor(s)

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