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Proceedings Paper

Noninvasive determination of concentration of compounds in strongly absorbing biological tissue
Author(s): Rene Alexander Bolt; Johannes Sake Kanger; Frits F. M. de Mul; Xiaomao Wu; Shu-Jen Yeh; Omar S. Khalil
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Paper Abstract

We describe a non-invasive method for the determination of optical parameters of highly scattering media, such as biological tissue. An advantage of this method is that it does not rely on diffusion theory, thus it is applicable to strongly absorbing media and at small source-detector separations. Monte Carlo simulations and phantom measurements are used to illustrate the achievable accuracy of the system. The method was applied to non-invasive in- vivo tracking of haemoglobin concentration in biological tissue. The results correlated well to clinically determined Hb concentrations.

Paper Details

Date Published: 19 April 2000
PDF: 8 pages
Proc. SPIE 3917, Optical Biopsy III, (19 April 2000); doi: 10.1117/12.382729
Show Author Affiliations
Rene Alexander Bolt, Univ. of Twente (Netherlands)
Johannes Sake Kanger, Univ. of Twente (Netherlands)
Frits F. M. de Mul, Univ. of Twente (Netherlands)
Xiaomao Wu, Abbott Labs. (United States)
Shu-Jen Yeh, Abbott Labs. (United States)
Omar S. Khalil, Abbott Labs. (United States)


Published in SPIE Proceedings Vol. 3917:
Optical Biopsy III
Robert R. Alfano, Editor(s)

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