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Proceedings Paper

Calcium detection of human hair and nail by the nanosecond time-gated spectroscopy of laser-ablation plume
Author(s): Masamitsu Haruna; Masato Ohmi; Mitsuo Nakamura; Shigeto Morimoto
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Paper Abstract

We demonstrate the nanosecond time-gated spectroscopy of plume in laser ablation of biological tissue, which allows us to detect calcium (Ca) with high sensitivity by the use of either a UV or a near-IR laser pulse. Clear and sharp peaks of Ca+ appear in the luminescence spectrum of laser-ablation plume although the Ca content is only 0.1 percent in human hair and nail. Luminescence peaks of sodium atom (Na) and ionized carbon are also detectable. This specific spectroscopy is low invasive because a single low-energy laser pulse illuminates the tissue sample, and it does not require any poisonous sensititizers like fluorescence dye. This method, therefore, is a promising candidate for optical biopsy in the near future. In particular, Ca detection of human hair may lead to new diagnosis, including monitor of daily intake of Ca and a screening diagnosis of osteoporosis.

Paper Details

Date Published: 19 April 2000
PDF: 6 pages
Proc. SPIE 3917, Optical Biopsy III, (19 April 2000); doi: 10.1117/12.382719
Show Author Affiliations
Masamitsu Haruna, Osaka Univ. School of Allied Health Sciences (Japan)
Masato Ohmi, Osaka Univ. School of Allied Health Sciences (Japan)
Mitsuo Nakamura, Osaka Univ. School of Allied Health Sciences (Japan)
Shigeto Morimoto, Osaka Univ. Graduate School of Medicine (Japan)


Published in SPIE Proceedings Vol. 3917:
Optical Biopsy III
Robert R. Alfano, Editor(s)

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