Share Email Print
cover

Proceedings Paper

Elastic scattering spectroscopy in vivo: optical biopsies of cancers of the breast and GI tract
Author(s): David Christopher O. Pickard; Gavin M. Briggs; Christobel Saunders; Sunil Lakhani; Paul M. Ripley; Irving J. Bigio; Stephen G. Bown
Format Member Price Non-Member Price
PDF $14.40 $18.00

Paper Abstract

Elastic scattering or diffuse reflectance spectroscopy offers the possibility of distinguishing between normal and neoplastic tissue with a relatively simple optical measurement. The measurement of the reflection of light has previously been shown to be sensitive to the size and distribution of both intra and inter-cellular structures as well as absorption from chromatophores which are present in the tissue. By coupling a white light source and spectrometer to optic fibers it is possible to construct probes which can be inserted precutaneously or intra- operatively into breast tissue or which can pass down the channel of an endoscope and take in-vivo spectra of diseased and normal tissue in the Gastro-Intestinal tract. Spectra are reported from a large number of patients with a variety of benign, metaplastic, dysplastic and cancerous conditions. Some differences that have been observed in these spectra are discussed and the merits and disadvantages of 'optical biopsy' as an in-vivo diagnostic tool are examined. It is shown that to a relatively high degree of sensitivity and specificity it is possible to distinguish cancerous from normal tissue in a number of cases. The methods of distinguishing spectra and some possible modalities for their improvement are discussed.

Paper Details

Date Published: 19 April 2000
PDF: 8 pages
Proc. SPIE 3917, Optical Biopsy III, (19 April 2000); doi: 10.1117/12.382717
Show Author Affiliations
David Christopher O. Pickard, National Medical Laser Ctr./Univ. College London (United Kingdom)
Gavin M. Briggs, National Medical Laser Ctr./Univ. College London (United Kingdom)
Christobel Saunders, National Medical Laser Ctr./Univ. College London (United Kingdom)
Sunil Lakhani, National Medical Laser Ctr./Univ. College London (United Kingdom)
Paul M. Ripley, Los Alamos National Lab. (United States)
Irving J. Bigio, Los Alamos National Lab. (United States)
Stephen G. Bown, National Medical Laser Ctr./Univ. College London (United Kingdom)


Published in SPIE Proceedings Vol. 3917:
Optical Biopsy III
Robert R. Alfano, Editor(s)

© SPIE. Terms of Use
Back to Top