Share Email Print
cover

Proceedings Paper

Vascular plaque characterization using intravascular ultrasound elastography and NIR Raman spectroscopy in vitro
Author(s): Chris L. de Korte; Hendrik P. J. Buschman; Sweder W. E. van de Poll; Anton F. W. van der Steen; Gerwin J. Puppels; Arnoud van der Laarse
Format Member Price Non-Member Price
PDF $14.40 $18.00
cover GOOD NEWS! Your organization subscribes to the SPIE Digital Library. You may be able to download this paper for free. Check Access

Paper Abstract

The composition and morphology of the atherosclerotic lesion are considered to be important determinants of acute coronary ischemic syndromes. We investigated the potentials of a combination of intravascular ultrasound (IVUS) elastography and intravascular Near Infrared Raman (NIR) spectroscopy, to assess the physical and chemical composition of the vessel wall and plaque. Intact human coronary arteries were mounted in an in vitro pressurized perfusion setup and investigated with a 20 MHz VisionsR IVUS catheter. At selected cross- sections, two echo-frames were acquired at intraluminal pressures of 80 and 100 mmHg to strain the tissue in order to obtain elastograms. Next, Raman spectra were obtained during 30 seconds at 4 angles (0, 90, 180 and 270 degrees) using a sideways viewing probe. Spectra were modeled to obtain quantitative chemical information, while leaving the specimens intact. Calcified areas were identifiable on the echograms, elastograms and Raman spectra. A combination of geometric information provided by the echogram, chemical information as obtained with Raman spectroscopy, and high stress regions determined by the elastogram, may prove to be a valuable tool to identify plaque vulnerability.

Paper Details

Date Published: 12 April 2000
PDF: 7 pages
Proc. SPIE 3982, Medical Imaging 2000: Ultrasonic Imaging and Signal Processing, (12 April 2000); doi: 10.1117/12.382223
Show Author Affiliations
Chris L. de Korte, Erasmus Univ. (Netherlands)
Hendrik P. J. Buschman, Leiden Univ. Medical Ctr. (Netherlands)
Sweder W. E. van de Poll, Leiden Univ. Medical Ctr. (Netherlands) and Interuniversity Cardiology Institute of the Ne (Netherlands)
Anton F. W. van der Steen, Erasmus Univ. (Netherlands) and Interuniversity Cardiology Institute of the Netherlands (Netherlands)
Gerwin J. Puppels, Erasmus Univ. (Netherlands)
Arnoud van der Laarse, Leiden Univ. Medical Ctr. (Netherlands) and Interuniversity Cardiology Institute of the Ne (Netherlands)


Published in SPIE Proceedings Vol. 3982:
Medical Imaging 2000: Ultrasonic Imaging and Signal Processing
K. Kirk Shung; Michael F. Insana, Editor(s)

© SPIE. Terms of Use
Back to Top