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Proceedings Paper

Confocal imaging of biological tissues using second harmonic generation
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Paper Abstract

A confocal microscopy imaging system was devised to selectively detect second harmonic signals generated by biological tissues. Several types of biological tissues were examined using this imaging system, including human teeth, bovine blood vessels, and chicken skin. All these tissues generated strong second harmonic signals. There is considerable evidence that the source of these signals in tissue is collagen. Collagen, the predominant component of most tissues, is known to have second order nonlinear susceptibility. This technique may have diagnostic usefulness in pathophysiological conditions characterized by changes in collagen structure including malignant transformation of nevi, progression of diabetic complications, and abnormalities in wound healing.

Paper Details

Date Published: 14 April 2000
PDF: 6 pages
Proc. SPIE 3927, Optical Pulse and Beam Propagation II, (14 April 2000); doi: 10.1117/12.382051
Show Author Affiliations
Beop-Min Kim, Lawrence Livermore National Lab. (South Korea)
Patrick Christian Stoller, Lawrence Livermore National Lab. (United States)
Karen M. Reiser, Univ. of California/Davis Medical Ctr. (United States)
Juergen P. Eichler, Technische Fachhochschule-Berlin (Germany)
Ming Yan, Lawrence Livermore National Lab. (United States)
Alexander M. Rubenchik, Lawrence Livermore National Lab. (United States)
Luiz Barroca Da Silva, Lawrence Livermore National Lab. (United States)


Published in SPIE Proceedings Vol. 3927:
Optical Pulse and Beam Propagation II
Yehuda B. Band, Editor(s)

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