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Proceedings Paper

Optically active nanoparticles for ultrasensitive detection and spectroscopy
Author(s): Dustin J. Maxwell; John T. Krug; Shuming Nie
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Paper Abstract

Recent research in our lab has identified a new class of metal nanoparticles that are highly efficient for surface- enhanced optical spectroscopy. By coupling nanoparticles with surface-enhanced Raman scattering (SERS), surface optical processes can be enhanced by 14 to 15 orders of magnitude. This enormous enhancement allows the optical detection of single molecules at room temperature. However, in a standard silver colloid only 1 out of 100 nanoparticles is SERS-active. In this report, a new methodology based on size-selective filtration is demonstrated. This size- selective fractionation procedure yields an enriched colloid that can be used to prepare highly efficient nanoparticle thin films.

Paper Details

Date Published: 11 April 2000
PDF: 8 pages
Proc. SPIE 3913, In-Vitro Diagnostic Instrumentation, (11 April 2000); doi: 10.1117/12.382024
Show Author Affiliations
Dustin J. Maxwell, Indiana Univ. (United States)
John T. Krug, Indiana Univ. (United States)
Shuming Nie, Indiana Univ. (United States)

Published in SPIE Proceedings Vol. 3913:
In-Vitro Diagnostic Instrumentation
Gerald E. Cohn, Editor(s)

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