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Proceedings Paper

Pharmaceutical applications of photothermal cytometry
Author(s): Dmitry Lapotko; Tat'yana Romanovskaya
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Paper Abstract

We describe two optical methods for in vitro drug trials on living cells and cell cultures. Response of each single target cell to drug impact is measured as the change of cell functional and structural state by photothermal imaging and the changes of cell viability is controlled with Laser Viability Test. Both photothermal methods are sensitive to specific cell reaction but although to reaction of general origin. High sensitivity of the methods allows to use minor amounts of drug and cell materials. Pharmaceutical applications are illustrated with the results of in vitro experiments being obtained for human living blood cells.

Paper Details

Date Published: 22 March 2000
PDF: 11 pages
Proc. SPIE 3926, Advances in Nucleic Acid and Protein Analyses, Manipulation, and Sequencing, (22 March 2000); doi: 10.1117/12.380518
Show Author Affiliations
Dmitry Lapotko, Luikov Heat and Mass Transfer Institute (United States)
Tat'yana Romanovskaya, International Sakharov Environmental Univ. (Belarus)

Published in SPIE Proceedings Vol. 3926:
Advances in Nucleic Acid and Protein Analyses, Manipulation, and Sequencing
Patrick A. Limbach; John C. Owicki; Ramesh Raghavachari; Weihong Tan, Editor(s)

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