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Proceedings Paper

Compact phase-sensitive multichannel detection system with array measurements of biosensor chips
Author(s): Emmanuil M. Rabinovich; Michael J. O'Brien; Steven R. J. Brueck; S. Yang; Victor H. Perez-Luna; Gabriel P. Lopez
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Paper Abstract

In many medical, biological, chemical, and environmental applications it is desirable not only to monitor one specific chemical or biological species, but several simultaneously. Thus, we have focused our efforts on development of a detection system for multi-analyte sensor arrays that is able to monitor the changes in fluorophore lifetimes (via the detection of phase shifts) corresponding to the presence of many analytes of interest in near-real time. We describe a phase-sensitive electronic detection system employing a multianode photomultiplier tube. This system utilizes the frequency-domain method of time-resolved spectroscopy and is also suitable for lifetime-based imaging.

Paper Details

Date Published: 22 March 2000
PDF: 5 pages
Proc. SPIE 3926, Advances in Nucleic Acid and Protein Analyses, Manipulation, and Sequencing, (22 March 2000); doi: 10.1117/12.380510
Show Author Affiliations
Emmanuil M. Rabinovich, Univ. of New Mexico (United States)
Michael J. O'Brien, Univ. of New Mexico (United States)
Steven R. J. Brueck, Univ. of New Mexico (United States)
S. Yang, Univ. of New Mexico (United States)
Victor H. Perez-Luna, Univ. of New Mexico (United States)
Gabriel P. Lopez, Univ. of New Mexico (United States)


Published in SPIE Proceedings Vol. 3926:
Advances in Nucleic Acid and Protein Analyses, Manipulation, and Sequencing
Patrick A. Limbach; John C. Owicki; Ramesh Raghavachari; Weihong Tan, Editor(s)

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