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Proceedings Paper

Protein mixture analysis by MALDI/mobility/time-of-flight mass spectrometry
Author(s): David H. Russell; Kent J. Gillig; Earle Stone; Zee-Yong Park; K. Fuhrer; M. Gonon; A. J. Schultz
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Paper Abstract

Progress in the development of ion mobility (IM) orthogonal time-of-flight (oTOF) mass spectrometry for rapid analysis of biological samples is presented. The IM-oTOF apparatus described consists of a short drift tube (1 to 15 cm) designed for ion mobility measurement in the low-field limit and a low resolution linear (20 cm) TOF mass spectrometer. Proof of concept is demonstrated by analysis of peptide mixtures generated by proteolytic digestion of proteins.

Paper Details

Date Published: 22 March 2000
PDF: 10 pages
Proc. SPIE 3926, Advances in Nucleic Acid and Protein Analyses, Manipulation, and Sequencing, (22 March 2000); doi: 10.1117/12.380496
Show Author Affiliations
David H. Russell, Texas A&M Univ. (United States)
Kent J. Gillig, Texas A&M Univ. (United States)
Earle Stone, Texas A&M Univ. (United States)
Zee-Yong Park, Texas A&M Univ. (United States)
K. Fuhrer, Ionwerks (United States)
M. Gonon, Ionwerks (United States)
A. J. Schultz, Ionwerks (United States)


Published in SPIE Proceedings Vol. 3926:
Advances in Nucleic Acid and Protein Analyses, Manipulation, and Sequencing
Patrick A. Limbach; John C. Owicki; Ramesh Raghavachari; Weihong Tan, Editor(s)

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