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Proceedings Paper

Clinical trials of photodynamic therapy of malignant brain tumors
Author(s): Paul J. Muller; Brian C. Wilson; Lothar D. Lilge; Victor X.D. Yang; Mike H. Hitchcock; Fred W. Hetzel; Qun Chen; T. Fullager; Robert Fenstermaker; Robert Selker; Judith Abrams
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Paper Abstract

Photodynamic therapy (PDT) is a local treatment for malignment tumors. In a phase 2 trial in patients with supratentorial gliomas treated with 2 mg/kg Photofrin i.v. and intraoperative cavitary PDT, we were able to conclude that PDT was safe in patients with either newly diagnosed or recurrent supratentorial malignant gliomas. There appears to be prolongation of survival in selected patients when an adequate light dose is used. The surgical mortality rate was less than 3 percent.

Paper Details

Date Published: 29 March 2000
PDF: 10 pages
Proc. SPIE 3909, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy IX, (29 March 2000); doi: 10.1117/12.379894
Show Author Affiliations
Paul J. Muller, St. Michael's Hospital and the Princess Margaret Hospital/Univ. of Toronto (Canada)
Brian C. Wilson, St. Michael's Hospital and the Princess Margaret Hospital/Univ. of Toronto (Canada)
Lothar D. Lilge, St. Michael's Hospital and the Princess Margaret Hospital/Univ. of Toronto (Canada)
Victor X.D. Yang, St. Michael's Hospital and the Princess Margaret Hospital/Univ. of Toronto (Canada)
Mike H. Hitchcock, The Swedish Medical Ctr. (United States)
Fred W. Hetzel, The Swedish Medical Ctr. (United States)
Qun Chen, The Swedish Medical Ctr. (United States)
T. Fullager, The Swedish Medical Ctr. (United States)
Robert Fenstermaker, Roswell Park Cancer Institute (United States)
Robert Selker, Penn West Hospital (United States)
Judith Abrams, Henry Ford Medical Ctr. (United States)


Published in SPIE Proceedings Vol. 3909:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy IX
Thomas J. Dougherty, Editor(s)

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