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Proceedings Paper

Novel drug form of chlorin e6
Author(s): Andrei V. Reshetnickov; Gelii V. Ponomarev; Olga Yu. Abakumova; Tatyana A. Tsvetkova; Artashes V. Karmenyan; Aleksei G. Rebeko; Rudolf Ph. Baum
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Paper Abstract

Chlorine6 has been known to be attractive as photosensitizer (PS) for PDT for long. Its usefulness as a photosensitizing part of photoimmunotoxines for targeted PDT, as a synton for further chemical modification and as a promising PS has been widely recognized. There is a patented procedure at our disposal now allowing for preparation of a stable, well soluble and filtrating form of chlorine6- 'Photodithazine'. The elaborated production technology includes 4 steps. 'Photodithazine's 1-octanol/Phosphate buffer, pH 7.4 partition coefficient has been found to be 1.4, indicating that it must be able to localize in the plasma membrane. This may be a partial explanation of its higher photodynamic efficacy in vitro, comparing to 'Photosense' and its closeness to 'Photogem'.

Paper Details

Date Published: 29 March 2000
PDF: 7 pages
Proc. SPIE 3909, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy IX, (29 March 2000); doi: 10.1117/12.379889
Show Author Affiliations
Andrei V. Reshetnickov, Institute of Biomedical Chemistry and JSC Veta (Russia)
Gelii V. Ponomarev, Institute of Biomedical Chemistry (Russia)
Olga Yu. Abakumova, Institute of Biomedical Chemistry (Russia)
Tatyana A. Tsvetkova, Institute of Biomedical Chemistry (Russia)
Artashes V. Karmenyan, N.N. Blokhin Cancer Research Ctr. (Russia)
Aleksei G. Rebeko, ChemBridge Corp. (Russia) (Russia)
Rudolf Ph. Baum, JSC Veta (Russia)


Published in SPIE Proceedings Vol. 3909:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy IX
Thomas J. Dougherty, Editor(s)

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