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Proceedings Paper

Motexafin lutetium in graft coronary artery disease
Author(s): Kathryn W. Woodburn; Shari L. Rodriquez; Atsushi Yamaguchi; Motoya Hayase; Robert C. Robbins; David Kessel
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Paper Abstract

Graft coronary artery disease (GCAD) is the chief complication following cardiac transplantation. Presently, there are limited treatment options. Insights into more expedient diagnosis and amelioration, if only partially, of GCAD are fervently sought. The selectivity of Antrin Injection (Lu-Tex) with subsequent photoactivation has been evaluated in several preclinical atherosclerosis models. The inhibitory effect of Lu-Tex induced photosensitization was demonstrated with human bypass coronary smooth muscle cells. The biodistribution of Lu-Tex was evaluated in a rat model of heterotopic cardiac allografts 60 days following transplantation. Lu-Tex was retained in the cardiac allograft, exhibiting a five-fold increase in retention between the allograft and native heart. These findings lead us to suggest that further studies are warranted to ascertain the merits of Lu-Tex for the diagnosis and possible attenuation of chronic graft vascular disease.

Paper Details

Date Published: 29 March 2000
PDF: 5 pages
Proc. SPIE 3909, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy IX, (29 March 2000); doi: 10.1117/12.379878
Show Author Affiliations
Kathryn W. Woodburn, Pharmacyclics, Inc. (United States)
Shari L. Rodriquez, Pharmacyclics, Inc. (United States)
Atsushi Yamaguchi, Stanford Univ. (United States)
Motoya Hayase, Stanford Univ. (United States)
Robert C. Robbins, Stanford Univ. (United States)
David Kessel, Wayne State Univ. School of Medicine (United States)

Published in SPIE Proceedings Vol. 3909:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy IX
Thomas J. Dougherty, Editor(s)

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