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Proceedings Paper

Raman chemical imaging using flexible fiberscope technology
Author(s): Ryan D. Smith; Matthew P. Nelson; Patrick J. Treado
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Paper Abstract

Raman chemical imaging microscopy has been proven to be a powerful methodology for analyzing a wide range of solid state materials. For biomedical applications, Raman chemical imaging has been shown to be effective in assessing clinical samples including breast tissue lesions and arterial plaques. With Raman chemical imaging systems based on microscopes, materials can be analyzed with molecular specificity, without labor intensive sample preparation or the use of dyes and stains at diffraction limited spatial resolution (< 250 nm). However, microscopes cannot readily be used to perform in vivo measurements. With the recent development of flexible fiberscope technology, Raman chemical imaging can be applied within remote and confined environments and the potential exists for in vivo use. This manuscript provides the first description of novel Raman chemical imaging fiberscope technology, including data analysis strategies for extracting information from Raman chemical imaging data sets.

Paper Details

Date Published: 14 March 2000
PDF: 7 pages
Proc. SPIE 3920, Spectral Imaging: Instrumentation, Applications, and Analysis, (14 March 2000); doi: 10.1117/12.379593
Show Author Affiliations
Ryan D. Smith, ChemIcon, Inc. (United States)
Matthew P. Nelson, ChemIcon, Inc. (United States)
Patrick J. Treado, ChemIcon, Inc. (United States)


Published in SPIE Proceedings Vol. 3920:
Spectral Imaging: Instrumentation, Applications, and Analysis
Gregory H. Bearman; Dario Cabib; Richard M. Levenson, Editor(s)

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