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Proceedings Paper

Mechanisms for protein micro-/nano-patterning on photopolymer substrates
Author(s): Dan V. Nicolau
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Paper Abstract

Two mechanisms can be applied initially for the high resolution patterning on radiation-assisted functionalized polymer surfaces: hydrophobicity-controlled patterning; and chemical linkage. The present contribution assesses the merits and drawbacks of these mechanisms in terms of resolution and contrast of protein/peptide features. Two microlithographic materials (an acrylate-based system and a diazo-naphto-quinone one); and two lithographic methods (e-beam and optical) have been used to test the merits of the protein patterning mechanisms. The hydrophobicity-controlled patterning produces sharp images but with multiple defects, whereas chemical linkage produces defect-free images but with a decreased contrast. The benefits of a third mechanism for protein confinement, namely bimolecular specific recognition, was explored in the view of the possible fabrication of artificial molecular motors.

Paper Details

Date Published: 15 March 2000
PDF: 6 pages
Proc. SPIE 3912, Micro- and Nanotechnology for Biomedical and Environmental Applications, (15 March 2000); doi: 10.1117/12.379568
Show Author Affiliations
Dan V. Nicolau, Swinburne Univ. of Technology (Australia)

Published in SPIE Proceedings Vol. 3912:
Micro- and Nanotechnology for Biomedical and Environmental Applications
Raymond P. Mariella, Editor(s)

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