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Proceedings Paper

Microfrabricated in-vitro cell culture systems for investigating cellular interactions: fabricating a model system for cardiac myocytes
Author(s): Jennifer Deutsch; Tejal A. Desai; Delara Motlagh; Brenda Russell
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Paper Abstract

The use of microfabricated and micromachined substrates can aid in the creation of design two- and three-dimensional microstructures, scaffolds, and platforms for cell culture and tissue engineering. These platforms may offer several advantages for in vitro cell culture by providing (1) well controlled microarchitectures, (2) spatial localization of different cell populations, and (3) biochemically modified substrates to promote selective protein and/or cell attachment. The development of methodologies to create microfabricated tissue engineering constructs using traditional natural and polymeric biomaterials may allow us to engineer highly controlled interfaces in order to better understand and modulate cell behavior and have the capability to provide: more physiologically relevant models of cell and tissues in vitro. This paper describes the use of microfabricated cell culture platforms to study cardiac myocytes.

Paper Details

Date Published: 15 March 2000
PDF: 9 pages
Proc. SPIE 3912, Micro- and Nanotechnology for Biomedical and Environmental Applications, (15 March 2000); doi: 10.1117/12.379567
Show Author Affiliations
Jennifer Deutsch, Univ. of Illinois/Chicago (United States)
Tejal A. Desai, Univ. of Illinois/Chicago (United States)
Delara Motlagh, Univ. of Illinois/Chicago (United States)
Brenda Russell, Univ. of Illinois/Chicago (United States)

Published in SPIE Proceedings Vol. 3912:
Micro- and Nanotechnology for Biomedical and Environmental Applications
Raymond P. Mariella Jr., Editor(s)

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