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Proceedings Paper

Novel drug form of chlorin e6
Author(s): O. Yu. Abakumova; Rudolf Ph. Baum; Natalia Yu. Ermakova; A. T. Gradyushko; T. N. Guseva-Donskaya; Artashes V. Karmenyan; U. M. Koraboyev; V. P. Laptev; V. M. Mechkov; L. M. Mikhailova; N. G. Panferova; Aleksei G. Rebeko; Andrei V. Reshetnickov; M. V. Ryabov; Eugeny Ph. Stranadko; Tatyana A. Tsvetkova; O. S. Zhukova
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Paper Abstract

A novel stable water-soluble form of well known photosensitizer chlorin e6 named `Photodithazine' has been obtained from Spirulina Platensis cyanobacteria as a noncovalent complex with N-methyl-D-glucosamine, and its biological characteristics evaluate, which proved to be as follows: in vitro photocytotoxicity was 1 (mu) M (EC50) as determined by the extent of DNA synthesis inhibition in CaOv cells after irradiation with 650 - 900 nm light, and 5 (mu) M (EC65) as determined using MTT test on PC12 cells after irradiation with 670 nm laser light at the doses of 15 and 20 J/cm2, respectively, with Al-sulfophthalocyanine `Photosense' (Russia) and oligomerized hematoporphyrin-IX mixture `Photogen' (Russia) being used as permitted reference drugs.

Paper Details

Date Published: 30 December 1999
PDF: 9 pages
Proc. SPIE 4059, Laser Use in Oncology II, (30 December 1999); doi: 10.1117/12.375256
Show Author Affiliations
O. Yu. Abakumova, Institute of Biomedical Chemistry (Russia)
Rudolf Ph. Baum, JSC Veta Ltd. (Russia)
Natalia Yu. Ermakova, N.N. Blokhin Cancer Research Ctr. (Russia)
A. T. Gradyushko, N.N. Blokhin Cancer Research Ctr. (Russia)
T. N. Guseva-Donskaya, State Research Ctr. for Laser Medicine (Russia)
Artashes V. Karmenyan, N.N. Blokhin Cancer Research Ctr. (Russia)
U. M. Koraboyev, State Research Ctr. for Laser Medicine (Russia)
V. P. Laptev, N.N. Blokhin Cancer Research Ctr. (Russia)
V. M. Mechkov, State Research Ctr. for Laser Medicine (Russia) and Ctr. of New Medical Technologies (Russia)
L. M. Mikhailova, N.N. Blokhin Cancer Research Ctr. (Russia)
N. G. Panferova, N.N. Blokhin Cancer Research Ctr. (Russia)
Aleksei G. Rebeko, ChemBridge Corp. (Russia)
Andrei V. Reshetnickov, Institute of Biomedical Chemistry (Russia) and JSC Veta Ltd. (Russia)
M. V. Ryabov, State Research Ctr. for Laser Medicine (Russia)
Eugeny Ph. Stranadko, State Research Ctr. for Laser Medicine (Russia)
Tatyana A. Tsvetkova, Institute of Biomedical Chemistry (Russia)
O. S. Zhukova, N.N. Blokhin Cancer Research Ctr. (Russia)


Published in SPIE Proceedings Vol. 4059:
Laser Use in Oncology II
Andrei V. Ivanov; Mishik A. Kazaryan, Editor(s)

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