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Proceedings Paper

Sensitized action of low-level laser radiation mechanism
Author(s): Tatyana V. Chichuk; Eugeny Ph. Stranadko; G. N. Lubchenko; E. V. Podgornaya; E. E. Pozdnyakova; Gennady I. Klebanov
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Paper Abstract

The goal of this work is to study the laser-induced photosensitized oxidation of lipids of the artificial (lyposomes) and cell's (erythrocytes, leukocytes) membranes and human blood lipoproteins. As a exogenous photosensitizers we are used hematoporphyrin derivatives (HPD) and sulfonated phthalocyanine aluminum (Pc). Irradiation was performed by helium-neon laser (632.8 nm). It was found out the increasing of the products of lipid oxidation in the suspensions of a lyposomes, human blood apo-(beta) -lipoproteins, erythrocytes and leucocytes. Accumulation of the lipid oxidation products depend on as irradiation dose as HPD or Pc concentrations. Interaction of photosensitizers with the lyposomes, lipoproteins and erythrocytes was investigated.

Paper Details

Date Published: 30 December 1999
PDF: 7 pages
Proc. SPIE 4059, Laser Use in Oncology II, (30 December 1999); doi: 10.1117/12.375253
Show Author Affiliations
Tatyana V. Chichuk, State Research Ctr. for Laser Medicine (Russia)
Eugeny Ph. Stranadko, State Research Ctr. for Laser Medicine (Russia)
G. N. Lubchenko, State Research Ctr. for Laser Medicine (Russia)
E. V. Podgornaya, State Research Ctr. for Laser Medicine (Russia)
E. E. Pozdnyakova, Russian State Medical Univ. (Russia)
Gennady I. Klebanov, Russian State Medical Univ. (Russia)

Published in SPIE Proceedings Vol. 4059:
Laser Use in Oncology II
Andrei V. Ivanov; Mishik A. Kazaryan, Editor(s)

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