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Proceedings Paper

AMBRI biosensor: stabilizing artificial membranes and receptor attachment
Author(s): Chris J. Burns; Vijoleta Braach-Maksvytis; L. G. King; Peter D. J. Osman; Ronald J. Pace; Burkhard Raguse; L. Wieczorek; B. A. Cornell
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Paper Abstract

The AMBRI Ion Channel Switch biosensor is a novel scanning technology with broad application in a variety of fields. The technology is based on an artificial bilayer membrane attached to gold through hydrophilic tethers. The lamellar bilayer membrane possesses electrical characteristics similar to black (bilayer) lipid membranes being sealed with a capacitance of approximately 0.6 (mu) F/cm2, is fluid, and is stable to a variety of media including plasma and whole blood and to challenges with solvent solutions. Receptors/antibodies can be attached to the membrane through biotin-streptavidin linkages, and use of caged biotin species allows optical patterning of the membrane surface.

Paper Details

Date Published: 15 December 1999
PDF: 8 pages
Proc. SPIE 3858, Advanced Materials and Optical Systems for Chemical and Biological Detection, (15 December 1999); doi: 10.1117/12.372925
Show Author Affiliations
Chris J. Burns, Ambri Pty Ltd. and Cooperative Research Ctr. for Molecular Engineering (Australia)
Vijoleta Braach-Maksvytis, Ambri Pty Ltd. and Cooperative Research Ctr. for Molecular Engineering (Australia)
L. G. King, Ambri Pty Ltd. and Cooperative Research Ctr. for Molecular Engineering (Australia)
Peter D. J. Osman, Ambri Pty Ltd. and Cooperative Research Ctr. for Molecular Engineering (Australia)
Ronald J. Pace, Ambri Pty Ltd. and Cooperative Research Ctr. for Molecular Engineering (Australia)
Burkhard Raguse, Ambri Pty Ltd. and Cooperative Research Ctr. for Molecular Engineering (Australia)
L. Wieczorek, Ambri Pty Ltd. and Cooperative Research Ctr. for Molecular Engineering (Australia)
B. A. Cornell, Ambri Pty Ltd. and Cooperative Research Ctr. for Molecular Engineering (Australia)


Published in SPIE Proceedings Vol. 3858:
Advanced Materials and Optical Systems for Chemical and Biological Detection
Mahmoud Fallahi; Basil I. Swanson, Editor(s)

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