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Proceedings Paper

Rapid biological agent identification by surface-enhanced Raman spectroscopy
Author(s): Stuart Farquharson; Wayne W. Smith; Susan Elliott; Jay F. Sperry
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Paper Abstract

The Chemical Weapons Convention prohibits the development, production, stockpiling, and use of warfare agents (chemical and biological), and requires their destruction. Yet their use persists and has been included in the terrorist's arsenal. Currently, a number of analytical methods are being developed to perform rapid measurements of trace agents to ensure treaty compliance, as well as safe environments for military personal and the public at large. We have been investigating the ability of surface-enhanced Raman spectroscopy to detect bacterial nucleic acid-base pairs with sufficient sensitivity and selectivity to eliminate the need for enumeration used in polymerase chain reactions and culture growth, required by other measurement techniques. The design of a small volume, fiber optic coupled, electrolytic sample cell is presented along with analysis of DNA and RNA separated from non-toxic bacteria.

Paper Details

Date Published: 30 November 1999
PDF: 7 pages
Proc. SPIE 3855, Air Monitoring and Detection of Chemical and Biological Agents II, (30 November 1999); doi: 10.1117/12.371269
Show Author Affiliations
Stuart Farquharson, Advanced Fuel Research, Inc. (United States)
Wayne W. Smith, Advanced Fuel Research, Inc. (United States)
Susan Elliott, Univ. of Rhode Island (United States)
Jay F. Sperry, Univ. of Rhode Island (United States)

Published in SPIE Proceedings Vol. 3855:
Air Monitoring and Detection of Chemical and Biological Agents II
Joseph Leonelli; Mark L.G. Althouse, Editor(s)

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