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Proceedings Paper

Sequential injection separation and sensing
Author(s): Jay W. Grate; Oleg B. Egorov; Cynthia J. Bruckner-Lea
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Paper Abstract

Automated microfluidic analysis has historically been carried out by flow injection analysis techniques. Sequential injection analysis represents a more versatile method for automated fluid handling. We have explored the use of sequential injection analysis for performing microcolumn separations. These separations can be used as part of a microanalytical procedure, or for sample preparation. In addition, with detection of retained species on the microcolumn, sequential injection separation represents a technique for sensing. Recently, it has been demonstrated that sequential injection separation can be carried out with renewable separation columns--the beads with interactive surfaces can be delivered to the microcolumn, used for processing the sample, and discarded after each measurement. Delivery of new beads for each measurement provides a method for renewable surface separation and renewable surface sensing. Applications in environmental analysis and bioanalytical chemistry will be presented.

Paper Details

Date Published: 18 November 1999
PDF: 4 pages
Proc. SPIE 3857, Chemical Microsensors and Applications II, (18 November 1999); doi: 10.1117/12.370272
Show Author Affiliations
Jay W. Grate, Pacific Northwest National Lab. (United States)
Oleg B. Egorov, Pacific Northwest National Lab. (United States)
Cynthia J. Bruckner-Lea, Pacific Northwest National Lab. (United States)

Published in SPIE Proceedings Vol. 3857:
Chemical Microsensors and Applications II
Stephanus Buettgenbach, Editor(s)

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