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Proceedings Paper

Autofluorescence spectrum of human lung tissue by Monte Carlo modeling
Author(s): Wei Zheng; Sanjay M. Krishnan; Zhiwei Huang; Teck-Chee Chia; Gilbert Chiang; Sing Lee
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Paper Abstract

Based on tissue microscopic fluorescence properties and optical parameters, a three-layer bronchus optical mode was developed to calculate the excitation light distribution in the tissue and the fluorescence escape function from the tissue by Monte Carlo simulations. The contributions of each layer in the tissue to total autofluorescence signal observed at the tissue surface were also estimated. In addition, the fluorescence spectrum of the bronchial tissue was also modeled using the obtained tissue micro- spectroscopic properties. It is found that the theoretically modeled spectrum agrees well with the in vitro tissue fluorescence in the spectral range below 520 nm or above 600 nm.

Paper Details

Date Published: 11 November 1999
PDF: 7 pages
Proc. SPIE 3897, Advanced Photonic Sensors and Applications, (11 November 1999); doi: 10.1117/12.369296
Show Author Affiliations
Wei Zheng, Nanyang Technological Univ. (Singapore)
Sanjay M. Krishnan, Nanyang Technological Univ. (Singapore)
Zhiwei Huang, Nanyang Technological Univ. (Canada)
Teck-Chee Chia, Nanyang Technological Univ. (Singapore)
Gilbert Chiang, Singapore General Hospital (Singapore)
Sing Lee, Nanyang Technological Univ. (Singapore)


Published in SPIE Proceedings Vol. 3897:
Advanced Photonic Sensors and Applications
Robert A. Lieberman; Anand Krishna Asundi; Hiroshi Asanuma, Editor(s)

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