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Proceedings Paper

Photothermal effect for arteriosclerotic region using infrared free electron lasers
Author(s): Kunio Awazu; Yuko Fukami
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Paper Abstract

Cholesteryl oleate can be selectively removed with an infrared free-electron laser (IFEL). To determine the mechanisms that are involved in the effects induced by IFEL, we compared the effect of FEL exposure and the effect of heating on a sample film and bulk sample of cholesteryl oleate. Heating is regarded as one of the mechanisms by which FEL ablates cholesteryl oleate that has accumulated on the arteriosclerotic region of arterial walls. FEL was applied at a wavelength of 5.75 micrometers and at several average powers (2 - 15 mW). FEL exposure induced melting and a decrease in the number of ester bonds. Using the value of absorbed IFEL- macropulse energy for each power density, the temperature was assumed to be 50 - 300 degree(s)C. In the heating experiment, the sample was heated from room temperature to 500 degree(s)C. Melting and carbonization were observed at 50 degree(s)C and 300 degree(s)C, respectively. We found that FEL exposure and heating each induced melting. FEL exposure induced chemical changes and ablation of cholesteryl oleate, although heating did not. Heating the cholesteryl oleate above 305 degree(s)C induced carbonization, although FEL exposure to the same temperature did not.

Paper Details

Date Published: 17 September 1999
PDF: 8 pages
Proc. SPIE 3863, 1999 International Conference on Biomedical Optics, (17 September 1999); doi: 10.1117/12.364423
Show Author Affiliations
Kunio Awazu, Free Electron Laser Research Institute (Japan)
Yuko Fukami, Free Electron Laser Research Institute (Japan)

Published in SPIE Proceedings Vol. 3863:
1999 International Conference on Biomedical Optics
Qingming Luo; Britton Chance; Lihong V. Wang; Steven L. Jacques, Editor(s)

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