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Proceedings Paper

FCLA-enhanced sonoluminescence imaging in vivo
Author(s): Yonghong He; Yonghong Tang; Shici Tan; Da Xing
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Paper Abstract

In this paper, we report, for the first time, sonoluminescence (SL) images of living body (nude mouse) injected with and without chemical agents under weak ultrasound field. We found FCLA (Fluoresceinyl Cypridina Luminescent Analog), a chemiluminescent analytic agent, could enhance SL and can work in vivo. We also makes use of sonosensitization to produce tumor-selective oxygen radicals that can react with FCLA to emit chemiluminescence. By detecting this luminescence, we obtained a clear diagnostic image. This novel method proposed by our group has potential application in clinics for tumor early-stage diagnosis.

Paper Details

Date Published: 17 September 1999
PDF: 5 pages
Proc. SPIE 3863, 1999 International Conference on Biomedical Optics, (17 September 1999); doi: 10.1117/12.364375
Show Author Affiliations
Yonghong He, South China Normal Univ. (China)
Yonghong Tang, South China Normal Univ. (China)
Shici Tan, South China Normal Univ. (China)
Da Xing, South China Normal Univ. (China)

Published in SPIE Proceedings Vol. 3863:
1999 International Conference on Biomedical Optics
Qingming Luo; Britton Chance; Lihong V. Wang; Steven L. Jacques, Editor(s)

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