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Proceedings Paper

PDT effects on cells and their optical spectroscopic research
Author(s): Songhao Liu; Timon Cheng-Yi Liu; Yao-Yong Meng
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Paper Abstract

In this paper, the roles that the light of PDT plays were classified into two kinds, PDT1 and PDT2. PDT1 is mediated by photosensitizer. PDT2 results from the direct interaction of light with target cells. As only the photosensitizers in the membrane of a cell can be in the coherent state, PDT1 is mediated by the coherent interaction of membrane photosensitizers, and its main target is the membranes of a cell. PDT2 is governed by the biological information model of low intensity laser (BIML) put forward by Liu TCY et al. According to BIML under the dose of PDT, cold-color (green, blue or violet) laser irradiation activates adenylate cyclase through Gs protein: cAMP$ARUP; hot color (red, orange or yellow) laser irradiation activates cAMP phosphodiesterase through Gi protein or activates phosphoinositide phospholipase C through Gq protein or activates one of receptor-linked enzyme: cAMP$ARDN. After reviewing simply the PDT effects on cells from the viewpoint of information biology and the research on them by use of optical spectroscopic approach, we arrived at the conclusion that cold color light PDT is better than hot color light PDT from the viewpoint of the effects on cell and the short term effects on cancer, but hot color light PDT is superior to cold color light PDT with respect to the long term effects on cancer.

Paper Details

Date Published: 17 September 1999
PDF: 5 pages
Proc. SPIE 3863, 1999 International Conference on Biomedical Optics, (17 September 1999); doi: 10.1117/12.364341
Show Author Affiliations
Songhao Liu, South China Normal Univ. (China)
Timon Cheng-Yi Liu, South China Normal Univ. (China)
Yao-Yong Meng, South China Normal Univ. (China)


Published in SPIE Proceedings Vol. 3863:
1999 International Conference on Biomedical Optics
Qingming Luo; Britton Chance; Lihong V. Wang; Steven L. Jacques, Editor(s)

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