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Proceedings Paper

Microchips for DNA sequencing
Author(s): Carlos H. Mastrangelo; S. Palaniappan; Piu Francis Man; Mark A. Burns; David T. Burke
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Paper Abstract

Genetic information is vital for understanding features and response of an organism. In humans, genetic errors are linked to the development of major diseases such as cancer and diabetes. In order to maximally exploit this information it is necessary to develop miniature sequencing assays that are rapid and inexpensive. In this paper we show how this could be attained with microfluidic chips that contain integrated assays. To date simple silicon/glass chips aimed for sequencing purpose have been realized; but these chips are not yet practical. Some of the solutions that are used to bring these devices closer to commercial applications are discussed.

Paper Details

Date Published: 19 August 1999
PDF: 6 pages
Proc. SPIE 3877, Microfluidic Devices and Systems II, (19 August 1999); doi: 10.1117/12.359324
Show Author Affiliations
Carlos H. Mastrangelo, Univ. of Michigan (United States)
S. Palaniappan, Univ. of Michigan (United States)
Piu Francis Man, Univ. of Michigan (United States)
Mark A. Burns, Univ. of Michigan (United States)
David T. Burke, Univ. of Michigan (United States)

Published in SPIE Proceedings Vol. 3877:
Microfluidic Devices and Systems II
Chong Hyuk Ahn; A. Bruno Frazier, Editor(s)

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