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Proceedings Paper

Superficial tissue optical property determination using spatially resolved measurements close to the source: comparison with frequency-domain photon migration measurements
Author(s): Frederic P. Bevilacqua; Dominique Piguet; Pierre Marquet; Jeffrey D. Gross; Dorota B. Jakubowski; Vasan Venugopalan; Bruce J. Tromberg; Christian D. Depeursinge
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Paper Abstract

Local and superficial optical property characterization of biological tissues can be performed by measuring spatially-resolved diffuse reflectance at small source-detector separations. Monte Carlo simulations and experiments were performed to assess the performance of a spatially-resolved reflectance probe, employing multiple detector fibers (0.3 to 1.4 mm from the source). Under these conditions, the inverse problem, i.e. calculating the absorption and reduced scattering coefficients, is necessarily sensitive to the phase function. This effect must be taken into account by considering a new parameter of the phase function, which depends on the first and second moments of the phase function. Probe performance is compared to another technique for quantitatively measuring optical coefficients, based on the analysis of photon density waves (Frequency Domain Photon Migration). The two techniques are found to be in reasonable agreement. However, the spatially resolved probe shows optimum measurement sensitivity in the volume immediately beneath the probe, while FDPM typically samples much larger regions of tissues. Measurements on human brain in vivo are reported using both methods.

Paper Details

Date Published: 15 July 1999
PDF: 8 pages
Proc. SPIE 3597, Optical Tomography and Spectroscopy of Tissue III, (15 July 1999); doi: 10.1117/12.356857
Show Author Affiliations
Frederic P. Bevilacqua, Ecole Polytechnique Federale de Lausanne (United States)
Dominique Piguet, Ecole Polytechnique Federale de Lausanne (Switzerland)
Pierre Marquet, Ecole Polytechnique Federala de Lausanne (Switzerland)
Jeffrey D. Gross, Beckman Laser Institute and Medical Clinic (United States)
Dorota B. Jakubowski, Beckman Laser Institute and Medical Clinic (United States)
Vasan Venugopalan, Beckman Laser Institute and Medical Clinic (United States)
Bruce J. Tromberg, Beckman Laser Institute and Medical Clinic (United States)
Christian D. Depeursinge, Ecole Polytechnique Federale de Lausanne (Switzerland)


Published in SPIE Proceedings Vol. 3597:
Optical Tomography and Spectroscopy of Tissue III
Britton Chance; Robert R. Alfano; Bruce J. Tromberg, Editor(s)

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