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Proceedings Paper

Image reconstruction of continuously varying objects and simulated breast cancer lesions
Author(s): Troy O. McBride; Brian W. Pogue; Ulf L. Oesterberg; Keith D. Paulsen
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Paper Abstract

Numerical simulations of near-infrared diffusion tomography are used to reconstruct absorption and scattering images of continuously varying objects and simulated breast cancer lesions. The breast cancer lesions are modeled using chromophore levels derived from typical breast anatomy and an approximation for breast cancer lesions based on contemporary investigations of tissue/tumor optical properties. Images of hemoglobin concentration and oxygenation are derived using least squares regressions on multiple wavelength near-infrared absorption images. The simulations are performed using finite element based iterative reconstructions. The results are compared with in vivo measurements of breast cancer patients acquired using near-infrared diffusion tomography.

Paper Details

Date Published: 15 July 1999
PDF: 12 pages
Proc. SPIE 3597, Optical Tomography and Spectroscopy of Tissue III, (15 July 1999); doi: 10.1117/12.356853
Show Author Affiliations
Troy O. McBride, Dartmouth College (United States)
Brian W. Pogue, Dartmouth College (United States)
Ulf L. Oesterberg, Dartmouth College (United States)
Keith D. Paulsen, Dartmouth College (United States)


Published in SPIE Proceedings Vol. 3597:
Optical Tomography and Spectroscopy of Tissue III
Britton Chance; Robert R. Alfano; Bruce J. Tromberg, Editor(s)

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