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Proceedings Paper

Accuracy limits in the determination of absolute optical properties using time-resolved NIR spectroscopy
Author(s): Vasilis Ntziachristos; Arjun G. Yodh; Britton Chance
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Paper Abstract

Time-resolved spectroscopy of tissue is considered to be a powerful tool in the NIR that can readily measure absorption and scattering properties of diffuse media. This can be done employing curve-shape fitting of the experimental measurements to the diffusion equation. Several experimental factors however can significantly affect the accuracy of the method and should be taken under consideration when quantitative measurements are desired. In this work we examine the influence of laser time drift and jitter, limited excitation of waveguide modes in multimode collection fibers and the finite width of the impulse response. The percent error in absorption coefficient calculation grows with an average rate of 5% error per 20 ps of time-uncertainty while the percent error in determining the reduced scattering coefficient increases with a rate of 10% per 20 ps of time uncertainty. Deconvolution is found necessary to compensate for photon dispersion higher than 50 ps. Furthermore the quantification accuracy is shown to be dependent on the medium optical properties in a non-linear fashion due to intrinsic time-characteristics of the diffusion process.

Paper Details

Date Published: 15 July 1999
PDF: 10 pages
Proc. SPIE 3597, Optical Tomography and Spectroscopy of Tissue III, (15 July 1999); doi: 10.1117/12.356849
Show Author Affiliations
Vasilis Ntziachristos, Univ. of Pennsylvania (United States)
Arjun G. Yodh, Univ. of Pennsylvania (United States)
Britton Chance, Univ. of Pennsylvania (United States)


Published in SPIE Proceedings Vol. 3597:
Optical Tomography and Spectroscopy of Tissue III
Britton Chance; Robert R. Alfano; Bruce J. Tromberg, Editor(s)

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